Toxicology Track

Weekly Newsletter of the MSU Center for Integrative Toxicology
Director: Norbert Kaminski/Editor: Lois Furry

March 10, 2008, Vol. 31, Number 10

Seminars this week / Seminars Upcoming /
Trainee Enrichment and Professional Development / Conferences and Other Events /
MSU Abstracts at the 2008 SOT Annual Meeting

Seminars this week

Tuesday, March 11
The Microbiology and Molecular Genetics Department presents Dr. Narayana Rao, Stanford University, to speak on “Inorganic Polyphosphate: A Biopolymer of Multiple Functions” on Tuesday, March 11, 2008 at 4:10 p.m. in 1415 Biomedical Physical Sciences.

Wednesday, March 12
*The Chemistry Department presents Dr. Jason Shearer, University of Nevada at Reno, to speak on “Biometric Model Compounds for Nickel Superoxide Dismutase: From Transition Metal Compleses to Metallopeptides” on Wednesday, March 12, 2008 at 11:20 a.m. in 136 Chemistry.

Thursday, March 13
*The Biochemistry and Molecular Biology program presents Dr. Hermann Steller, Rockefeller University, to speak on “Death by Degradation Regulation of Apoptosis by Ubiquitin Pathway Proteins” on Thursday, March 13, 2008 at 11:30 a.m. in 101 Biochemistry.

*The Department of Civil and Environmental Engineering presents Dr. Menachem Elimelech, Yale University, to speak on “Aggregation Behavior and Cytotoxicity of Carbon-Based Nanomaterials in Aquatic Environments” on Thursday, March 13, 2008 at 4 p.m. in 3540 Engineering Building.

The Department of Geological Sciences presents Dr. Michael Celia, Princeton University, to speak on “Geological Storage as a Carbon Mitigation Option” on Thursday, March 13, 2008 at 4:10 p.m. in 204 Natural Sciences.

The Neuroscience Program presents Dr. Michael Wiest, Duke University, to speak on “Somatosensory Integration in Behaving Rats” on Thursday, March 13, 2008 at 12:30 p.m. in 1425 Biomedical Physical Sciences.

Friday, March 14
*The Department of Pathobiology and Diagnostic Investigation presents Camilo Bulla, DVM, to speak on “Steriod Responsive Idiopathic Neutropenia: Comparison of Two Cases and Literature Review” on Friday, March 14, 2008 at 12 noon in 101 Diagnostic Center for Population and Animal Health, 4125 Beaumont Road.

*Fulfills seminar requirements for the Environmental and Integrative Toxicological Sciences Graduate Programs. Seminars that fulfill this requirement are archived at Seminar List.

Seminars Upcoming

*The Graduate School presents Dr. Brian Martinson, Senior Research Investigator, Health Partners Research, Minneapolis, to give the Hans Kende Memorial Lecture on “Scientists’ Misbehaviors and their Relationship with Mentoring” on Wednesday, March 18, 2008 at 3:30 p.m. in Big Ten A, Kellogg Center. For more information and to register, to to http://grad.msu.edu/pdf/Kende%20flyer.pdf.

*The Department of Food Science and Human Nutrition presents Dr. Laura McCabe, MSU ,to speak on “Disease and Osteoporosis - Understanding Mechanisms of Bone Loss Associated with Type I Diabetes and Inflammatory Bowel Diseases” on Wednesday, March 19, 2008 at 4 p.m. in 1135 S. Anthony Hall.

*Fulfills seminar requirements for the Environmental and Integrative Toxicological Sciences Graduate Programs. Seminars that fulfill this requirement are archived at Seminar List.

Trainee Enrichment and Professional Development

The Graduate School presents the following workshops and seminars open to all MSU graduate students. A calendar of these workshops is also available at http://www.grad.msu.edu/stuwork.htm.

"Navigating the Ph.D.: A Writing Workshop Series Part I; Demystifying the Dissertation, Personal Managment, Forming Committees, Working with Committees, and Comprehensive Exams" on Saturday, March 15, 2008 from 9 a.m. to 3 p.m. in 300 Bessey Hall. (Part I will also offered on March 22, 2008). Students are encouraged to also register for Part II (see April 12 workshop listed below). For more information, go to http://writing.msu.edu/ntp/.

“From CV to Resume: Developing Written Credentials for Nonacademic Positions” on Thursday, March 19, 2008 from 5 to 7 p.m. in 6 Student Services. For more information and to register, go to http://grad.msu.edu/current/jobseries.htm.

“Mastering the Interview” on Wednesday, March 26, 2008 from 5 to 7 p.m. in 6 Student Services. For more information and to register, go to http://grad.msu.edu/current/jobseries.htm#interview.

“Identify the Obstacles To Your Thesis/Dissertation” on Saturday, March 29, 2008. For more information and to register, go to http://www.grad.msu.edu/stuwork.htm.

“Translating Academic Success into Expanded Career Opportunities in Agencies, Industry, and Academia” on Saturday, April 5, 2008 in Big Ten B, Kellogg Center. For more information and to register, go to http://grad.msu.edu/professional.htm.

"Navigating the Ph.D.: A Writing Workshop Series Part II; Topics and Proposals, Writing Strategies, Revision Strategies, The Defense, and Beyond" on Saturday, April 12, 2008 from 9 a.m. to 3 p.m. in 300 Bessey Hall. (Part II will also offered on April 19, 2008). Students are encouraged to also register for Part I (see March 15, 2008 workshop listed above). For more information, go to http://writing.msu.edu/ntp/.

Conferences and Other Events

If you are making plans to attend the 2008 Society of Toxicology Annual Meeting in Seattle next month, please include the MSU Center for Integrative Toxicology's Alumni and Friends Reception in your itinerary.  The CIT reception will be held on Tuesday, March 18, 2008 from 9 to 11 p.m. in the Sheraton Seattle Hotel & Tower's Wallingford Room.  Dessert and coffee will be served.  A cash bar will be available. An invitation flyer is available at http://www.cit.msu.edu/News/SOT2008.pdf.

The National Science Foundation (NSF) is looking for exceptional science and engineering graduate students for the NSF-sponsored project Debating Science. Graduate students in the humanities and social sciences working on science and technology issues are also encouraged to apply. The program explores the debates surrounding global climate change, nanotechnology and agricultural biotechnology. It consists of a 5-day workshop (August 4 - 8, 2008) at The University of Montana-Missoula and an online course. The National Science Foundation provides support for program participants to attend the workshop in Missoula and covers tuition for the online course. Please visit our Web site for details. Interested students can find more information and apply online at http://www.umt.edu/ethics/debating_science.

Professional Analytical and Consulting Services (PACS) will provide short courses on spectroscopy, chromatography, environmental safety, technical writing, and advanced carbon. For a complete schedule and course offerings, check the PACS website at www.pacslabs.com or call 724. 457. 6756. These courses are provided in New Orleans, LA in March; Las Vegas, NV in March; Houston, TX in April; Pittsburgh, PA in May; Baltimore, MD in June; Boston, MA in July.

MSU Scientist's Abstracts at the 2008 SOT Meeting

The following abstracts by MSU-CIT affiliated scientists will be presented at the Society of Toxicology's 2008 Annual Meeting in Seattle, Washington, March 17-20:

Bauer Lab

• NRF2-mediated signaling: role in lung inflammation and tumorigenesis. S. R. Kleeberger; A. K. Bauer; X. Wang; D. A. Bell.

Bursian Lab

• Pharmacokinetic Evaluation Of Exposure to Ecologically Relevant Concentrations of 2,3,7,8-Tcdf And 2,3,4,7,8-PECDF in Mink (Mustela Vison). L. L. Aylward; M. Zwiernik; S. Bursian; D. Kay ; J. Moore; J. Rowlands; K. Woodburn; J. Khim; J. Giesy; R. Budinsky.

Ganey/Roth Labs

• Inflammation-mediated Liver Injury in Rats Cotreated with Sulindac and Lipopolysaccharide. W. Zou; S. S. Devi; H. S. Younis; R. A. Roth; P. E. Ganey.

• Trovafloxacin enhances the inflammatory response to a gram-negative or a gram-positive stimulus, resulting in neutrophil-dependent liver injury in mice. P. J. Shaw; P. E. Ganey; R. A. Roth.
• Coexposure of mice to trovafloxacin and lipopolysaccharide results in a unique gene expression profile and vascular endothelial growth factor (VEGF)-dependent liver injury. R. A. Roth; P. J. Shaw; A. C. Ditewig; J. F. Waring; M. J. Liguori; E. A. Blomme; D. M. Briscoe; P. E. Ganey.
• Hemostatic system activation contributes to hepatotoxicity in mice treated with trovafloxacin and lipopolysaccharide. A. M. Fullerton; P. J. Shaw; P. E. Ganey; R. A. Roth.
• Role of P38 MAPK kinase in TNF-α production and liver injury in hepatotoxic interaction of lipopolysaccharide and Ranitidine. X. Deng; J. Lu; L. Lehman-McKeeman; E. Malle; P. Ganey; R. Roth.
• Determinants of Sensitivity to Halothane-Induced Hepatotoxicity in Mice. C. M. Dugan; R. A. Roth; P. E. Ganey.
• Dioxin alters inflammatory responses to lipopolysaccharide. P. E. Ganey; J. T. Olivero; R. A. Robert.
• Microarray analysis of trovafloxacin-induced gene expression changes in human hepatocytes compared to hepatocytes isolated from rats treated with LPS. E. Sparkenbaugh; P. Shaw; P. E. Ganey; R. A. Roth; A. Ditewig; E. G. Blomme; M. Liguori; J. F. Waring.

Ganey/Roth/Harkema Labs

• Endotoxin enhances acetaminophen-induced nasal toxicity in mice. N. Birmingham; D. Ibrahim Aibo; J. F. Maddox; S. W. Newport; R. A. Roth; P. E. Ganey; J. R. Harkema.

Ganey/Roth/Harkema/Maddox Labs

• Synergistic toxic effects of acetaminophen and ozone on murine nasal epithelium. D. Ibrahim Aibo; N. Birmingham; J. F. Maddox; S. W. Newport; R. A. Roth; P. E. Ganey J. G. Wagner; J. R. Harkema.

Ganey/Roth/Maddox Labs

• Role of Tissue Factor and Protease Activated Receptor-1 in Acetaminophen-induced Hepatotoxicity in Mice. J. P. Luyendyk; P. E. Ganey; S. W. Newport; T. M. Eagle; J. F. Maddox; N. Mackman; R. A. Roth.

Goodman Lab

• Orphan Nuclear Receptor Constitutive Active/Androstane Receptor (CAR)-mediated Alterations in DNA Methylation during Phenobarbital (PB) Promotion of Liver Tumorigenesis. J. I. Goodman; J. M. Phillips.

• Phenobarbital (PB) Alters the Methylation Status of Key Genes During Early Phases of Tumorigenesis. J. M. Phillips; J. I. Goodman.
• Carcinogenicity Hazard Assessment of Hair Dyes: Is There A Biologically Plausable Cancer Risk? J. I. Goodman.
• Cigarette Smoke (CS) Causes Formation of Regions of Altered DNA Methylation (RAMs) in SENCAR Mouse Lung. J. I. Goodman; J. M. Phillips; G. M. Curtin; D. J. Doolittle.

Harkema Lab

• Propylene oxide: Biomarkers of exposure, nasal cell proliferation, and cancer mode-of-action in rats and mice exposed via inhalation. L. H. Pottenger; J. A. Hotchkiss; S. M. Krieger; J. R. Harkema; M. I. Banton; J. A. Swenberg.

• Oxidant Air Pollution and Childhood Asthma. L. S. Van Winkle; J. R. Harkema.
• Comparing Gene Expression Patterns in Blood and Lung Tissue of Immunologically-challenged Rats Exposed to Concentrated Airborne Particulates. D. Reif ; B. Heidenfelder; E. Hubal; J. R. Harkema; J. Gallagher.

Harkema/LaPres Labs

• Understanding Cobalt Chloride-Induced Lung Injury Through Cytometric, Metabolomic, Proteomic, and Histological Analysis of Bronchioalveolar Lavage Fluid (BALF). Y. Saini; J. Harkema; J. LaPres.

Harkema/Pestka Labs

• Tissue Distribution of the Macrocyclic Trichothecene Satratoxin G Following Intranasal Instillation in the Mouse. C. J. Amuzie; Z. I. Islam; J. R. Harkema; J. J. Pestka.

• Purification and Toxicity Characterization of Satratoxin G and Roridin L2from the Black Mold Stachybotrys chartarum. Z. Islam; J. R. Harkema; J. J. Pestka.

Harkema/Wagner Labs

• Ozone-Induced Injury in the Immature/Developing Nasal Airways of Infants. J. R. Harkema; S. A. Carey; J. G. Wagner; E. M. Postlethwait.

• Ozone Exposure Exacerbates Eosinophilic and Epithelial Cell Responses in Sinus and Nasolacrimal Duct Airways in Allergic Rats. J. G. Wagner; M. E. Swinkey; J. R. Harkema; D. B. Peden.

Kaminski Lab

• 2,3,7,8-Tetrachlorodibenzo-P-Dioxin-Mediated Impairment of B Cell Differentiation Through Deregulation of Paired Box Gene 5 (PAX5). M. A. Manzan; D. Schneider; N. E. Kaminski.

• A Cox-2 Metabolite Of 2-Arachidonyl Glycerol Is Involved In The Suppression Of Il-2 Secretion In Activated Jurkat T Cells. P. Raman; C. E. Rockwell; B. L. Kaplan; N. E. Kaminski.
• Suppression of B cell differentiation by 2,3,7,8- tetrachlorodibenzo-p-dioxin J. E. Suárez; N. E. Kaminski.
• The mechanism by which cannabidiol, a plant-derived cannabinoid, suppresses immune function involves suppression of nuclear factor of activated T cells (NFAT) transcriptional activation, but not suppression of NFATc1 or NFATc2 mRNA expression. B. L. Kaplan; N. E. Kaminski.
• Suppression of T Cell Co-Stimulator Icos by Delta-9-Tetrahydrocannabinol. H. Lu; B. L. Kaplan; N. E. Kaminski.
• Simultaneous Time Course and Dose Response Characterization of 2,3,7,8- Tetrachlorodibenzo-Para-Dioxin Effects on the In Vivo LPS-Activated Primary Igm Response In Female C57bl6 Mice. C. M. North; R. B. Crawford; H. Lu; N. E. Kaminski.

LaPres Lab

• AHR Protein Interactions: Building a Comprehensive Protein Interaction Network. D. M. Tappenden; L. Yang; R. S. Thomas; J. J. LaPres.

Madhukar Lab

• Proapoptotic interactions of non-planar PCBs in rat liver epithelial cells: role of mitogen-activated protein kinases. B. V. Madhukar; G. Chen.

Pestka Lab

• Comparison of 28S rRNA Cleavage by Ricin and Trichothecene Deoxynivalenol in RAW 264.7 Macrophages. M. Li; J. Pestka.

• Tissue Distribution of the Macrocyclic Trichothecene Satratoxin G Following Intranasal Instillation in the Mouse. C. J. Amuzie; Z. I. Islam; J. R. Harkema; J. J. Pestka.
• Deoxynivalenol-Induced Map Kinase Activation Mediated Via the Ribosome Can Induce Robust Proinflammatory Gene Expression and Apoptosis in Mononuclear Phagocytes. H. Bae; J. J. Pestka.
• Unfolded Protein Response Induced in Macrophages by the Trichothecene Deoxynivalenol. Y. Shi; J. J. Pestka.
• Effect of n-3 and n-6 Polyunsaturated Fatty Acid Consumption on Deoxynivalenol-Induced Tissue-Specific IL-6 Expression in Mice. L. L. Vines; J. J. Pestka.

Trosko /Upham Labs

• Mechanisms of inhibition of gap junction intercellular communication through different molecular pathways. J. Park; I. Sovadinova; P. Babica; A. Wilke; H. Boke; L. Kleinow; E. Kumar; J. E. Trosko; B. L. Upham.

• Role of Cx32 in steady-state hematopoiesis and leukemogenesis: study in the Cx32-knockout mice. Y. Hirabayashi; B. Yoon; I. Tsuboi; Y. Kodama; J. Kanno; J. E. Trosko; T. Inoue.
• The effects of polycyclic aromatic hydrocarbons on gap junction function in an adult human liver stem cell line. B. L. Upham; P. Babica; J. Park; I. Sovadinova; J. E. Trosko; C. Chang.
• 3-Methylthio-propionic acid ethyl ester enhanced differentiation in well-differentiated human colon cancer cells. Y. Nakamura; Y. Nakayama; A. Tanaka; T. Matsuo; S. Okamoto; B. L. Upham; C. Chang; J. E. Trosko; E. Park; K. Sato.

Zacharewski Lab

• Identification of Positionally Conserved Dioxin Response Elements in Orthologous Human, Mouse, and Rat Genes. A. Cabunoc; L. D. Burgoon; T. R. Zacharewski.

• A Community-Based Deliberation Platform for Debating Dioxin and Dioxin-like Chemical Toxic Equivalency Data and Assigned Factors. L. D. Burgoon; T. R. Zacharewski.
• Effects Of Tcdd On Liver Lipid Metabolism - Mouse Versus Rat. M. K. Makley; M. N. Kent; N. V. Reo; G. L. Jahns; N. J. DelRaso; D. Boverhof; L. Burgoon; D.
  Jump; T. Zacharewski.
• Comparative Metabolomic Analysis of Hepatotoxicity Experiments in Rats and Mice. G. L. Jahns; N. V. Reo; M. N. Kent; M. K. Makley; A. Kopec; D. R. Boverhof; L. Burgoon; T. R. Zacharewski; N. DelRaso.
• Comparative Hepatic Gene Expression Elicited by O,P'-Ddt In The Rat and Mouse. T. R. Zacharewski; J. C. Kwekel; L. D. Burgoon; N. Kiyosawa.
• Temporal and Dose-dependent AhR-Mediated Gene Expression Analysis in Human Liver Adult Stem Cells. S. Kim; E. Dere; L. D. Burgoon; C. C. Chang; T. R. Zacharewski.
• Characterization of Gene Expression Responses Elicited by Toxic and Non-Toxic AHR Ligands in Murine Hepa1c1c7 Cells. E. Dere; A. W. Lee; M. S. Kiewitt; L. D. Burgoon; T. R. Zacharewski.
• Conserved And Divergent Gene Expression Profiles During Ethynylestradiol, Tamoxifen and O,P’-Ddt Induced Uterotrophy in the Rat Uterus. J. C. Kwekel;; K. J. Williams; T. R. Zacharewski.

 

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