Center for Integrative Toxicology at Michigan State University

Toxicology Track

Weekly Newsletter of the MSU Center for Integrative Toxicology
Director: Norbert Kaminski/Editor: Lois Furry

March 17, 2008, Vol. 31, Number 11

Seminars this week / Trainee Enrichment and Professional Development /
Conferences and Other Events / MSU Abstracts at the 2008 SOT Annual Meeting /
Postions

Seminars this week

Tuesday, March 18
The College of Osteopathic Medicine presents J. Alan Diehl, Ph.D, University of Pennsylvania and Abramson Family Cancer Research Institute, to speak on "Coordinated Regulation of Tumor Cell Proliferation and Adaptation" on Tuesday, March 18, 2008 at 9 a.m. in 1425 Biomedical and Physical Sciences Building. Dr. Diehl is a candidate for the MSU Patenge Endowed Professorship in Cancer Biology.

The Microbiology and Molecular Genetics Department presents Julie Dunning, Hotopp, to speak on “Lateral Gene Transfer from Bacteria to Animals” on Tuesday, March 18, 2008 at 4:10 p.m. in 1415 Biomedical Physical Sciences.

The Center for Systems Integration and Sustainability and the Department of Fisheries and Wildlife present the Rachel Carson Distinguished Lecture by Dr. Ruth DeFries, University of Maryland, who will speak on “Changing Dynamics of Tropical Deforestation and Atmospheric Carbon Emissions” on Tuesday, March 18, 2008 at 3 p.m. in the Red Cedar Room at the MSU Kellogg Center.

Wednesday, March 19
*The Graduate School presents Dr. Brian Martinson, Senior Research Investigator, Health Partners Research, Minneapolis, to give the Hans Kende Memorial Lecture on “Scientists’ Misbehaviors and their Relationship with Mentoring” on Wednesday, March 19, 2008 at 3:30 p.m. in Big Ten A, Kellogg Center. For more information and to register, to to http://grad.msu.edu/pdf/Kende%20flyer.pdf.

*The Department of Food Science and Human Nutrition presents Dr. Laura McCabe, MSU ,to speak on “Disease and Osteoporosis - Understanding Mechanisms of Bone Loss Associated with Type I Diabetes and Inflammatory Bowel Diseases” on Wednesday, March 19, 2008 at 4 p.m. in 1135 S. Anthony Hall.

Thursday, March 20
The Biochemistry and Molecular Biology program presents Dr. Bonnie Bassler, Princeton University, to speak on “Small Talk: Cell-to-Cell Communication” on Thursday, March 20, 2008 at 11:30 a.m. in 101 Biochemistry.

The Neuroscience Program presents Dr. Ming Guo, University of California-Los Angeles, to speak on “Studying Alzheimer’s and Parkinson’s Disease Using Drosophila as a Model” on Thursday, March 20, 2008 at 12:30 p.m. in 1425 Biomedical Physical Sciences.

*Fulfills seminar requirements for the Environmental and Integrative Toxicological Sciences Graduate Programs. Seminars that fulfill this requirement are archived at Seminar List.

Trainee Enrichment and Professional Development

The Graduate School presents the following workshops and seminars open to all MSU graduate students. A calendar of these workshops is also available at http://www.grad.msu.edu/stuwork.htm.

"Navigating the Ph.D.: A Writing Workshop Series Part I; Demystifying the Dissertation, Personal Managment, Forming Committees, Working with Committees, and Comprehensive Exams" on Saturday, March 22, 2008 from 9 a.m. to 3 p.m. in 300 Bessey Hall. Students are encouraged to also register for Part II (see April 12 workshop listed below). For more information, go to http://writing.msu.edu/ntp/.

“From CV to Resume: Developing Written Credentials for Nonacademic Positions” on Wednesday, March 19, 2008 from 5 to 7 p.m. in 6 Student Services. For more information and to register, go to http://grad.msu.edu/current/jobseries.htm.

"A Dissertation Support Group" is beginning on Tuesday, March 25, 2008 from 12 noon to 1 p.m. and on subsequent Tuesdays through April 22, 2008. This group is to support graduate students who are currently working on their doctoral dissertations. A process of sharing, goal-setting, and mutual accountability is used to assist ABDs in becoming Ph.D.s. A light lunch will be provided (pizza and beverages). REGISTRATION IS REQUIRED. To register, please send an e-mail to gradwrsp@msu.edu with the following 5 pieces of information: your
name, department, e-mail address, workshop name, and date of workshop.

“Mastering the Interview” on Wednesday, March 26, 2008 from 5 to 7 p.m. in 6 Student Services. For more information and to register, go to http://grad.msu.edu/current/jobseries.htm#interview.

“Identify the Obstacles To Your Thesis/Dissertation” on Saturday, March 29, 2008. For more information and to register, go to http://www.grad.msu.edu/stuwork.htm.

“Translating Academic Success into Expanded Career Opportunities in Agencies, Industry, and Academia” on Saturday, April 5, 2008 in Big Ten B, Kellogg Center. For more information and to register, go to http://grad.msu.edu/professional.htm.

"Navigating the Ph.D.: A Writing Workshop Series Part II; Topics and Proposals, Writing Strategies, Revision Strategies, The Defense, and Beyond" on Saturday, April 12, 2008 from 9 a.m. to 3 p.m. in 300 Bessey Hall. (Part II will also offered on April 19, 2008). Students are encouraged to also register for Part I (see March 22, 2008 workshop listed above). For more information, go to http://writing.msu.edu/ntp/.

Conferences and Other Events

If you are making plans to attend the 2008 Society of Toxicology Annual Meeting in Seattle next month, please include the MSU Center for Integrative Toxicology's Alumni and Friends Reception in your itinerary.  The CIT reception will be held on Tuesday, March 18, 2008 from 9 to 11 p.m. in the Sheraton Seattle Hotel & Tower's Wallingford Room.  Dessert and coffee will be served.  A cash bar will be available. An invitation flyer is available at http://www.cit.msu.edu/News/SOT2008.pdf.

The National Science Foundation (NSF) is looking for exceptional science and engineering graduate students for the NSF-sponsored project Debating Science. Graduate students in the humanities and social sciences working on science and technology issues are also encouraged to apply. The program explores the debates surrounding global climate change, nanotechnology and agricultural biotechnology. It consists of a 5-day workshop (August 4 - 8, 2008) at The University of Montana-Missoula and an online course. The National Science Foundation provides support for program participants to attend the workshop in Missoula and covers tuition for the online course. Please visit our Web site for details. Interested students can find more information and apply online at http://www.umt.edu/ethics/debating_science.

Professional Analytical and Consulting Services (PACS) will provide short courses on spectroscopy, chromatography, environmental safety, technical writing, and advanced carbon. For a complete schedule and course offerings, check the PACS website at www.pacslabs.com or call 724. 457. 6756. These courses are provided in New Orleans, LA in March; Las Vegas, NV in March; Houston, TX in April; Pittsburgh, PA in May; Baltimore, MD in June; Boston, MA in July.

MSU Scientist's Abstracts at the 2008 SOT Meeting

The following abstracts by MSU-CIT affiliated scientists will be presented at the Society of Toxicology's 2008 Annual Meeting in Seattle, Washington, March 17-20:

Bauer Lab

  • NRF2-mediated signaling: role in lung inflammation and tumorigenesis. S. R. Kleeberger; A. K. Bauer; X. Wang; D. A. Bell.

Bursian Lab

  • Pharmacokinetic Evaluation Of Exposure to Ecologically Relevant Concentrations of 2,3,7,8-Tcdf And 2,3,4,7,8-PECDF in Mink (Mustela Vison). L. L. Aylward; M. Zwiernik; S. Bursian; D. Kay ; J. Moore; J. Rowlands; K. Woodburn; J. Khim; J. Giesy; R. Budinsky.

Ganey/Roth Labs

  • Inflammation-mediated Liver Injury in Rats Cotreated with Sulindac and Lipopolysaccharide. W. Zou; S. S. Devi; H. S. Younis; R. A. Roth; P. E. Ganey.

  • Trovafloxacin enhances the inflammatory response to a gram-negative or a gram-positive stimulus, resulting in neutrophil-dependent liver injury in mice. P. J. Shaw; P. E. Ganey; R. A. Roth.
  • Coexposure of mice to trovafloxacin and lipopolysaccharide results in a unique gene expression profile and vascular endothelial growth factor (VEGF)-dependent liver injury. R. A. Roth; P. J. Shaw; A. C. Ditewig; J. F. Waring; M. J. Liguori; E. A. Blomme; D. M. Briscoe; P. E. Ganey.
  • Hemostatic system activation contributes to hepatotoxicity in mice treated with trovafloxacin and lipopolysaccharide. A. M. Fullerton; P. J. Shaw; P. E. Ganey; R. A. Roth.
  • Role of P38 MAPK kinase in TNF-α production and liver injury in hepatotoxic interaction of lipopolysaccharide and Ranitidine. X. Deng; J. Lu; L. Lehman-McKeeman; E. Malle; P. Ganey; R. Roth.
  • Determinants of Sensitivity to Halothane-Induced Hepatotoxicity in Mice. C. M. Dugan; R. A. Roth; P. E. Ganey.
  • Dioxin alters inflammatory responses to lipopolysaccharide. P. E. Ganey; J. T. Olivero; R. A. Robert.
  • Microarray analysis of trovafloxacin-induced gene expression changes in human hepatocytes compared to hepatocytes isolated from rats treated with LPS. E. Sparkenbaugh; P. Shaw; P. E. Ganey; R. A. Roth; A. Ditewig; E. G. Blomme; M. Liguori; J. F. Waring.

Ganey/Roth/Harkema Labs

  • Endotoxin enhances acetaminophen-induced nasal toxicity in mice. N. Birmingham; D. Ibrahim Aibo; J. F. Maddox; S. W. Newport; R. A. Roth; P. E. Ganey; J. R. Harkema.

Ganey/Roth/Harkema/Maddox Labs

  • Synergistic toxic effects of acetaminophen and ozone on murine nasal epithelium. D. Ibrahim Aibo; N. Birmingham; J. F. Maddox; S. W. Newport; R. A. Roth; P. E. Ganey J. G. Wagner; J. R. Harkema.

Ganey/Roth/Maddox Labs

  • Role of Tissue Factor and Protease Activated Receptor-1 in Acetaminophen-induced Hepatotoxicity in Mice. J. P. Luyendyk; P. E. Ganey; S. W. Newport; T. M. Eagle; J. F. Maddox; N. Mackman; R. A. Roth.

Goodman Lab

  • Orphan Nuclear Receptor Constitutive Active/Androstane Receptor (CAR)-mediated Alterations in DNA Methylation during Phenobarbital (PB) Promotion of Liver Tumorigenesis. J. I. Goodman; J. M. Phillips.

  • Phenobarbital (PB) Alters the Methylation Status of Key Genes During Early Phases of Tumorigenesis. J. M. Phillips; J. I. Goodman.
  • Carcinogenicity Hazard Assessment of Hair Dyes: Is There A Biologically Plausable Cancer Risk? J. I. Goodman.
  • Cigarette Smoke (CS) Causes Formation of Regions of Altered DNA Methylation (RAMs) in SENCAR Mouse Lung. J. I. Goodman; J. M. Phillips; G. M. Curtin; D. J. Doolittle.

Harkema Lab

  • Propylene oxide: Biomarkers of exposure, nasal cell proliferation, and cancer mode-of-action in rats and mice exposed via inhalation. L. H. Pottenger; J. A. Hotchkiss; S. M. Krieger; J. R. Harkema; M. I. Banton; J. A. Swenberg.

  • Oxidant Air Pollution and Childhood Asthma. L. S. Van Winkle; J. R. Harkema.
  • Comparing Gene Expression Patterns in Blood and Lung Tissue of Immunologically-challenged Rats Exposed to Concentrated Airborne Particulates. D. Reif ; B. Heidenfelder; E. Hubal; J. R. Harkema; J. Gallagher.

Harkema/LaPres Labs

  • Understanding Cobalt Chloride-Induced Lung Injury Through Cytometric, Metabolomic, Proteomic, and Histological Analysis of Bronchioalveolar Lavage Fluid (BALF). Y. Saini; J. Harkema; J. LaPres.

Harkema/Pestka Labs

  • Tissue Distribution of the Macrocyclic Trichothecene Satratoxin G Following Intranasal Instillation in the Mouse. C. J. Amuzie; Z. I. Islam; J. R. Harkema; J. J. Pestka.

  • Purification and Toxicity Characterization of Satratoxin G and Roridin L2from the Black Mold Stachybotrys chartarum. Z. Islam; J. R. Harkema; J. J. Pestka.

Harkema/Wagner Labs

  • Ozone-Induced Injury in the Immature/Developing Nasal Airways of Infants. J. R. Harkema; S. A. Carey; J. G. Wagner; E. M. Postlethwait.

  • Ozone Exposure Exacerbates Eosinophilic and Epithelial Cell Responses in Sinus and Nasolacrimal Duct Airways in Allergic Rats. J. G. Wagner; M. E. Swinkey; J. R. Harkema; D. B. Peden.

Kaminski Lab

  • 2,3,7,8-Tetrachlorodibenzo-P-Dioxin-Mediated Impairment of B Cell Differentiation Through Deregulation of Paired Box Gene 5 (PAX5). M. A. Manzan; D. Schneider; N. E. Kaminski.

  • A Cox-2 Metabolite Of 2-Arachidonyl Glycerol Is Involved In The Suppression Of Il-2 Secretion In Activated Jurkat T Cells. P. Raman; C. E. Rockwell; B. L. Kaplan; N. E. Kaminski.
  • Suppression of B cell differentiation by 2,3,7,8- tetrachlorodibenzo-p-dioxin J. E. Suárez; N. E. Kaminski.
  • The mechanism by which cannabidiol, a plant-derived cannabinoid, suppresses immune function involves suppression of nuclear factor of activated T cells (NFAT) transcriptional activation, but not suppression of NFATc1 or NFATc2 mRNA expression. B. L. Kaplan; N. E. Kaminski.
  • Suppression of T Cell Co-Stimulator Icos by Delta-9-Tetrahydrocannabinol. H. Lu; B. L. Kaplan; N. E. Kaminski.
  • Simultaneous Time Course and Dose Response Characterization of 2,3,7,8- Tetrachlorodibenzo-Para-Dioxin Effects on the In Vivo LPS-Activated Primary Igm Response In Female C57bl6 Mice. C. M. North; R. B. Crawford; H. Lu; N. E. Kaminski.

LaPres Lab

  • AHR Protein Interactions: Building a Comprehensive Protein Interaction Network. D. M. Tappenden; L. Yang; R. S. Thomas; J. J. LaPres.

Madhukar Lab

  • Proapoptotic interactions of non-planar PCBs in rat liver epithelial cells: role of mitogen-activated protein kinases. B. V. Madhukar; G. Chen.

Pestka Lab

  • Comparison of 28S rRNA Cleavage by Ricin and Trichothecene Deoxynivalenol in RAW 264.7 Macrophages. M. Li; J. Pestka.

  • Tissue Distribution of the Macrocyclic Trichothecene Satratoxin G Following Intranasal Instillation in the Mouse. C. J. Amuzie; Z. I. Islam; J. R. Harkema; J. J. Pestka.
  • Deoxynivalenol-Induced Map Kinase Activation Mediated Via the Ribosome Can Induce Robust Proinflammatory Gene Expression and Apoptosis in Mononuclear Phagocytes. H. Bae; J. J. Pestka.
  • Unfolded Protein Response Induced in Macrophages by the Trichothecene Deoxynivalenol. Y. Shi; J. J. Pestka.
  • Effect of n-3 and n-6 Polyunsaturated Fatty Acid Consumption on Deoxynivalenol-Induced Tissue-Specific IL-6 Expression in Mice. L. L. Vines; J. J. Pestka.

Trosko /Upham Labs

  • Mechanisms of inhibition of gap junction intercellular communication through different molecular pathways. J. Park; I. Sovadinova; P. Babica; A. Wilke; H. Boke; L. Kleinow; E. Kumar; J. E. Trosko; B. L. Upham.

  • Role of Cx32 in steady-state hematopoiesis and leukemogenesis: study in the Cx32-knockout mice. Y. Hirabayashi; B. Yoon; I. Tsuboi; Y. Kodama; J. Kanno; J. E. Trosko; T. Inoue.
  • The effects of polycyclic aromatic hydrocarbons on gap junction function in an adult human liver stem cell line. B. L. Upham; P. Babica; J. Park; I. Sovadinova; J. E. Trosko; C. Chang.
  • 3-Methylthio-propionic acid ethyl ester enhanced differentiation in well-differentiated human colon cancer cells. Y. Nakamura; Y. Nakayama; A. Tanaka; T. Matsuo; S. Okamoto; B. L. Upham; C. Chang; J. E. Trosko; E. Park; K. Sato.

Zacharewski Lab

  • Identification of Positionally Conserved Dioxin Response Elements in Orthologous Human, Mouse, and Rat Genes. A. Cabunoc; L. D. Burgoon; T. R. Zacharewski.

  • A Community-Based Deliberation Platform for Debating Dioxin and Dioxin-like Chemical Toxic Equivalency Data and Assigned Factors. L. D. Burgoon; T. R. Zacharewski.
  • Effects Of Tcdd On Liver Lipid Metabolism - Mouse Versus Rat. M. K. Makley; M. N. Kent; N. V. Reo; G. L. Jahns; N. J. DelRaso; D. Boverhof; L. Burgoon; D.
    Jump; T. Zacharewski.
  • Comparative Metabolomic Analysis of Hepatotoxicity Experiments in Rats and Mice. G. L. Jahns; N. V. Reo; M. N. Kent; M. K. Makley; A. Kopec; D. R. Boverhof; L. Burgoon; T. R. Zacharewski; N. DelRaso.
  • Comparative Hepatic Gene Expression Elicited by O,P'-Ddt In The Rat and Mouse. T. R. Zacharewski; J. C. Kwekel; L. D. Burgoon; N. Kiyosawa.
  • Temporal and Dose-dependent AhR-Mediated Gene Expression Analysis in Human Liver Adult Stem Cells. S. Kim; E. Dere; L. D. Burgoon; C. C. Chang; T. R. Zacharewski.
  • Characterization of Gene Expression Responses Elicited by Toxic and Non-Toxic AHR Ligands in Murine Hepa1c1c7 Cells. E. Dere; A. W. Lee; M. S. Kiewitt; L. D. Burgoon; T. R. Zacharewski.
  • Conserved And Divergent Gene Expression Profiles During Ethynylestradiol, Tamoxifen and O,P’-Ddt Induced Uterotrophy in the Rat Uterus. J. C. Kwekel;; K. J. Williams; T. R. Zacharewski.

Positions

The MSU-CIT Environmental and Integrative Toxicological Sciences program has an open postdoctoral position. Research programs of the faculty employ modern technologies at the molecular, cellular and in vivo levels to explore mechanisms by which toxicants cause tissue injury. Areas of interest include cell signaling, molecular targets, immune/inflammatory responses, gene-environment interactions, susceptibility factors, control of gene expression, hemostasis, fibrogenesis and endocrine disruption in neuronal, respiratory, hepatic, cardiovascular, and immune tissues. Toxic agents of interest include drugs, air pollutants (particulate matter, ozone, mycotoxins) and water and food contaminants (plant and microbial toxins, metals, chlorinated hydrocarbons, etc.) and others. Research funding derives from the NIH and other federal sources (EPA, DOE) and includes a multi-investigator NIEHS/EPA Superfund Program Project grant. The toxicology faculty at MSU collaborate extensively with each other and with colleagues at other academic and industrial institutions; this provides numerous opportunities for postdoctoral fellows to engage in collaborative research that broadens their investigative and networking horizons. This postdoctoral position is supported by a training grant from the NIEHS and is accordingly limited to applicants who are US citizens or permanent residents. Interested applicants should visit the website of the Center for Integrative Toxicology and send a curriculum vitae that includes a short description of research interests, training and experience and three references to Amy Swagart, Center for Integrative Toxicology, Food Safety and Toxicology Building, Michigan State University, East Lansing, Michigan 48824 or by email to swagart@msu.edu. Questions about the position should be addressed to Robert Roth, PhD, Director, EITS Training Program, at rothr@msu.edu or 517-353-9841.

An animal health pharmaceutical and biologicals company has an opportunity for a Senior Scientist. The ideal candidate for this position is a DVM with 5+ years in clinical practice with some research experience as well as some pathology in their background. This position will work across more than one entity and will contribute to the process of discovering and developing Animal Health product candidates. In this role, the individual will participate in protocol development and experimental design, test article administration, necropsy and data management. This position will require excellent oral and written communication and organization skills, resourcefulness, independent initiative and flexibility. To confidentially learn more about this opportunity, e-mail your resume in confidence to Principal Scientist - AH Drug Discovery, resumes@thevetrecruiter.com.

LimnoTech (LTI) has a current need for a Project Manager to focus on Contaminated Sediments working out of our Ann Arbor, MI or Washington, D.C. offices. Primary responsibilities of the Project Manager include: Manage clients (including industrial clients, engineering firms, attorneys, regulatory agencies) and staff while working on projects in the contaminated sediments area, including site characterization, remedial investigation, numerical modeling, and remedy evaluation and design. Assist in growing LimnoTech's services for management of contaminated sediment sites, building on and expanding our client base in the industrial, regulatory, and municipal arenas. Provide technical expertise in the arena of contaminated sediments through activities such as presenting at regional and national conferences, publishing papers, and serving on state, regional, or national committees. The ideal candidate possesses: at least five years of demonstrated project management experience and the ability to manage people, multiple tasks, and objectives; demonstrated knowledge of the contaminated sediments technical area, the body of sediment regulations, and the role of site characterization, monitoring and modeling in support of contaminated sediments remedy design and decision-making; demonstrated, successful consulting work experience in related project areas; willingness to travel as needed, mainly within the U.S.; and advanced degree(s) in relevant science or engineering program. LTI offers a competitive compensation package and a diverse and technically challenging work environment with a focus on individual job satisfaction. To apply, forward your resume and salary requirements to: sgartland@comcast.net. For more information, visit www.limno.com.

LimnoTech (LTI) has a current need for a Project Manager to focus on Wet Weather working out of our Ann Arbor, MI or Washington, D.C. offices. Primary responsibilities of the Project Manager include: Manage clients (including municipalities, A/E firms, attorneys, regulatory agencies) and staff while working on projects that require expertise in assessing the magnitude of wet weather discharges and impacts on watersheds and water quality, and developing solutions that meet Clean Water Act requirements (e.g., CSO Policy, TMDLs, NPDES permits). Assist in growing LimnoTech's services for management of wet weather pollutant sources, including combined sewer overflows (CSOs), sanitary sewer overflows (SSOs), storm water and peak excess flows at municipal wastewater treatment plants. Provide technical expertise in the arena of wet weather pollutant sources and the Clean Water Act through activities such as presenting at regional and national conferences, publishing papers, and serving on state, regional, or national committees. The ideal candidate possesses: excellent interpersonal and oral and written communication skills; at least five years of demonstrated project management experience and ability to mange people, multiple tasks, and objectives; demonstrated knowledge of Clean Water Act programs, water quality standards, wet weather pollutant sources, and the role of monitoring and modeling of collection systems, watersheds, and water quality in decision-making; demonstrated, successful consulting work experience in related project areas; willingness to travel as needed, mainly within the U.S.; and advanced degree(s) in relevant science or engineering program. LTI offers a competitive compensation package and a diverse and technically challenging work environment with a focus on individual job satisfaction. To apply, forward your resume and salary requirements to: sgartland@comcast.net. For more information, visit www.limno.com.

A research project training opportunity for faculty and/or postgraduates is currently available at the U.S. Environmental Protection Agency (EPA) National Center for Environmental Assessment (NCEA) in Arlington, Virginia. This project is with the Integrated Risk Information System (IRIS) Program which is part of the Immediate Office of the NCEA Director. The IRIS Program develops health assessments for chemicals of concern to EPA and provides a nationally and internationally used data base of toxicity information that is utilized in risk assessments, site-specific environmental decisions, and rule-making. The selected individual will be trained in tasks related to IRIS health assessments. This might include the scientific analysis and development of multiple, concurrent health assessments for IRIS in accordance with a set of priorities and a schedule, response to peer review and EPA consensus review comments, interaction with other scientists to identify and resolve scientific issues in a timely manner, and completion of final IRIS summaries and support documents for the data base. The selected individual will also learn through interactions with other individuals and teams on cross-cutting scientific issues that arise in the IRIS Program. The Research Participation Program for NCEA is administered by the Oak Ridge Institute for Science and Education. Please reference Project # EPA-NCEA 2008-02 when calling or writing for information. For additional information and application materials contact: Research Participation Program/NCEA-RTP, Attn: Betty Bowling, Oak Ridge Institute for Science and Education, P.O. Box 117, Oak Ridge, Tennessee 37831-0117, Phone: (865) 576-8503 FAX: (865) 241-5219 e-mail: betty.bowling@orau.org. An application can be found at www.orau.gov/orise/edu/EPA/app-gugrgpd.pdf

 

This newsletter is produced and distributed weekly by the Center for IntegrativeToxicology. We appreciate suggestions regarding information that might be included in this publication. To be added to the e-mail list, send your name and e-mail address to: Lois Furry, Editor, Center for Integrative Toxicology, Michigan State University, 165C Food Safety and Toxicology Building, East Lansing, MI 48824; furry@msu.edu; 517/353-6469(phone), 517/355-4603(fax).