Toxicology Track

Weekly Newsletter of the MSU Center for Integrative Toxicology
Director: Norbert Kaminski/Editor: Lois Furry

March 19, 2007, Vol. 30, Number 11

Seminars/Publications/Conferences/Positions/

Seminars

The Department of Pharmacology and Toxicology present Sheba MohanKumar, MSU, to speak on "Neuroimmune Interactions: Effects on the Hypotalamo-Pituitary-Gonadal Axis" on Wednesday, March 21, 2007 at 12 noon in B448-49 Life Sciences.

*The Neuroscience Program presents Dr.  Albert La Spada, University of Washington, to speak on "Androgen Receptor Polyglutamine Neurotoxicity in SBMA Motor Neuron Degeneration" on Wednesday, March 21, 2007 at 12:15 p.m. in 1425 Biomedical Physical Sciences.

*The Neuroscience Program presents Dr. Christine Wagner, University of Albany, to speak on "Progesterone Receptors in Neural Development: Regulation and Potential Function" on Thursday, March 22, 2007 at 12:15 p.m. in 1425 Biomedical Physical Sciences.

The Department of Geological Sciences and Shell Oil Company present John Rakovan, Miami University, to speak on "REE Incorporation in Apatite: Surface Structural Controls and Crystal Chemistry" on Thursday, March 22, 2007 at 4 p.m. in 204 Natural Science.

The Department of Chemistry presents Eric Jacobsen, Harvard University, to give the Pfizer Distinguished Letureship on "A Search for Selective Yet General Catalysts" on Thursday, March 22, 2007 at 4:10 p.m. in 138 Chemistry.

CANCELLED*The Department of Biochemistry and Molecular Biology presents Nevan Krogan, University of California-San Francisco, to speak on "Biology without Bias: Functional Insights from High Resolution Genetic and Protein-Protein Interaction Maps" on Friday, March 23, 2007 at 11:30 a.m. in 101 Biochemistry.

The Department of Chemistry presents Eric Jacobsen, Harvard University, to give the Pfizer Distinguished Letureship on "A Symmetric Catalysis by Chiral Hydrogen-Bond Donors" on Friday, March 23, 2007 at 4:10 p.m. in 138 Chemistry.

*Fulfills seminar requirements for the Environmental and Integrative Toxicological Sciences Graduate Programs.  Seminars that fulfill this requirement are archived at seminars.

Publications

Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. Dahl M, Bauer AK, Arredouani M, Soininen R, Tryggvason K, Kleeberger SR, Kobzik L. J Clin Invest. 2007 Mar 1;117(3):757-764.
 
Interleukin-1R antagonist gene and pre-natal smoke exposure are associated with childhood asthma. Ramadas RA, Sadeghnejad A, Karmaus W, Arshad SH, Matthews S, Huebner M, Kim DY, Ewart SL. Eur Respir J. 2007 Mar;29(3):502-8. Epub 2006 Nov 15.
 
Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis. Phillips JM, Yamamoto Y, Negishi M, Maronpot RR, Goodman JI. Toxicol Sci. 2007 Mar;96(1):72-82.
 
Evaluation of Effects from Repeated Inhalation Exposure of F344 Rats to High Concentrations of Propylene. Pottenger L, Malley L, Bogdanffy M, Donner E, Upton P, Li Y, Walker V, Harkema J, Banton M, Swenberg J. Toxicol Sci. 2007 Mar 6; [Epub ahead of print].
 
Considerations when using discriminant function analysis of antimicrobial resistance profiles to identify sources of fecal contamination of surface water in Michigan, USA. Kaneene JB, Miller R, Sayah R, Johnson YJ, Gilliland D, Gardiner JC.  Appl Environ Microbiol. 2007 Mar 2; [Epub ahead of print]
 
Prevalence of antimicrobial resistance among Salmonella on midwest and northeast USA dairy farms. Ray KA, Warnick LD, Mitchell RM, Kaneene JB, Ruegg PL, Wells SJ, Fossler CP, Halbert LW, May K. Prev Vet Med. 2007 May 16;79(2-4):204-23.
 
Prolyl-hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype. Irwin R, LaPres JJ, Kinser S, McCabe LR. J Cell Biochem. 2007 Feb 15;100(3):762-72.
 
Heaves, genes, nerves, and Victorians. Robinson NE, Wilson MR. J Vet Intern Med. 2007 Jan-Feb;21(1):1-2.
 
Identifying the genetic basis of ecologically and biotechnologically useful functions of the bacterium Burkholderia vietnamiensis. O'sullivan LA, Weightman AJ, Jones TH, Marchbank AM, Tiedje JM, Mahenthiralingam E. Environ Microbiol. 2007 Apr;9(4):1017-34.
 
Characterization of Urban Atmospheres during Inhalation Exposure Studies in Detroit and Grand Rapids, Michigan.  Keeler GJ, Morishita M, Wagner JG, Harkema JR. Toxicol Pathol. 2007;35(1):15-22.
 
Evaluation of Effects from Repeated Inhalation Exposure of F344 Rats to High Concentrations of Propylene. Pottenger L, Malley L, Bogdanffy M, Donner E, Upton P, Li Y, Walker V, Harkema J, Banton M, Swenberg J. Toxicol Sci. 2007 Mar 6; [Epub ahead of print].
 
dbZach toxicogenomic information management system. Burgoon LD, Zacharewski TR. Pharmacogenomics. 2007 Mar;8(3):287-91.

Conferences

The Society of Toxicology's 46th Annual Meeting takes place March 25-29, 2007 in Charlotte, North Carolina (http://www.toxicology.org/ai/meet/am2007/index.asp). All MSU alumni, current students, faculty, or friends attending the meeting are invited to the Center for Integrative Toxicology Alumni and Friends Reception on Monday, March 26, 2007 from 9-11 p.m. in the Westin Charlotte Trade Room. Dessert and coffee will be served. Cash bar available.

The 2007 National Forum on Contaminants in Fish, sponsored by the U.S. EPA and the Maine Center for Disease Control and Prevention, will take place July 23-26, 2007 in Portland, ME.  Poster submissions will be accepted until June 1, 2007.  For more information, go to http://epa.gov/waterscience/fish/.

Positions

The Center for Integrative Toxicology (CIT) at Michigan State University invites applications for a tenure-track academic year faculty position at the Assistant or Associate Professor level in chemical carcinogenesis or developmental toxicology. The CIT has over 40 affiliated faculty members and administers a Superfund Program Project grant and a Training grant, both awarded by the NIH, NIEHS. We are seeking candidates with expertise in either chemical carcinogenesis or developmental toxicology to strengthen our growing interest in these areas. Candidates should have a Ph.D. degree in Toxicology or a related discipline, postdoctoral research experience and demonstrated success in obtaining extramural funding. This position involves a joint appointment in the CIT and in a biomedical science department (e.g., Biochemistry & Molecular Biology, Food Science and Human Nutrition, Pharmacology & Toxicology, Physiology) consistent with his/her expertise and interests. In addition to contributing to the CIT, the candidate will have the opportunity to participate in one or more other interdisciplinary research and training programs including the National Food Safety and Toxicology Center, the Center for Biological Modeling, Breast Cancer and the Environment Research Centers and the Genetics and Neuroscience Programs. He/she will be expected to establish and maintain an independent and extramurally-funded research program and to contribute to the teaching and service missions of the department and the CIT. Interested individuals should send their curriculum vitae, statement of research interests and future research plans, and 3 letters of recommendation to: Chair, Faculty Search Committee, Center for Integrative Toxicology, 165C Food Safety and Toxicology Building, Michigan State University, East Lansing, MI 48824. Electronic submissions may be sent to: swagart@msu.edu. Review of applications will begin March 2007 and will continue until the position is filled.

The Electric Power Research Institute (EPRI), a collaborative, non-profit research institute located in Palo Alto, California, is seeking a health sciences professional to join its Air Quality Health and Risk Assessment Program. This individual will be responsible for the planning and management of leading edge environmental and health risk research projects. EPRIs environmental research programs are internationally recognized for leadership in Air Quality and Health; Climate Change; Water and Groundwater Issues; Electric and Magnetic Field Effects; and Occupational Health & Safety. This position provides an opportunity to join a group of internationally recognized experts focused on addressing some of the most vexing environmental challenges facing society. This interdisciplinary position is well suited for individuals with a penchant for conducting and publishing research of outstanding quality and who can anticipate and lead cutting edge research. The successful candidate will provide effective management for environmental projects that include health effects studies, biological risk assessment, and environmental health sciences. The individual will contribute to the leadership of a national research program by defining problems and products, establishing teams of scientists in academia and private institutions to solve them, and delivering results within allocated time and resources. Areas of responsibility will include: health effects investigations of environmental toxicants; examination of human exposure pathways and processes; technical management of integrative research projects on human health and environmental sciences. During the first year the successful candidate is also expected to work in the EPRI Office of Innovation to actively scan and identify innovative concepts in health sciences for possible application in addressing issues facing the electric power industry and its consumers/customers. Qualifications: Ph.D. or equivalent advanced degree with complementary experience in environmental or health sciences, especially toxicology, public health, or allied health fields. Minimum 5 years relevant and distinguished experience in environmental sciences or public health issues. Excellent teaming abilities so as to work successfully with multidisciplinary staff, contracted resources, and the scientific and technical community at large to collect and assess information on new, innovative technical opportunities Excellent oral and written communications skills Ability to communicate research issues, approaches, and findings with non-specialists as well as with scientists and research program executives. Send resumes to resumes@epri.com.

The Kaiser Permanente Center for Health Research Hawaii (CHRH) is a nonprofit organization that is strategically focused on advancing knowledge to improve the health of diverse populations through world-leading, innovative, interdisciplinary and translational research. A primary research laboratory is the population of Kaiser Permanente members, nearly a quarter of the states multi-ethnic population, and its electronic medical database and research clinic. Through linkages with Kaiser Permanente Research Centers nationwide, other health-maintenance organizations and health-care systems, research institutes, and university collaborations, the CHRH conducts professionally autonomous research in areas uniquely suited to our setting. Current areas of research include epidemiology, health services, psychology, informatics, behavior change, nutrition, translational research, medical outcomes, and community based participatory research. We seek a Researcher to complement our group. The successful candidate will develop a competitively funded research program, publish findings in peer-reviewed journals, and participate in related professional activities. Applicants must have a PhD, MD, or equivalent degree. We seek an experienced investigator with a solid record of scholarly publication, demonstrated ability to obtain national funding, and project management experience.
Apply online for job #55212 at http://jobs.kaiserpermanente.org. For inquiries about CHRH or this position, please contact: Kanani Chan Kanani.chan@kp.org Center for Health Research, Hawaii 501 Alakawa Street, Suite 201 Honolulu, Hawaii 96817.

The University of Florida College of Public Health and Health Professions invites applications for a 12-month, tenure track position in environmental health. The College has been intensively engaged in developing educational, research, and service programs in public health since 2001. Development in the area of environmental health is integral to these efforts and consistent with university wide initiatives. The director of the Environmental Health Program may be appointed at the assistant, associate, or full professor level. The individual will lead in the creation, management and future development of the program and, ultimately, a department of environmental health, teach in the Colleges rapidly growing MPH program, collaborate with other faculty within the College and throughout the university, and build on the strong research traditions of UF while addressing key Public Health issues in the state of Florida and the southeast region. The successful applicant must hold an appropriate doctoral degree in an environmental health-related discipline and demonstrate the ability to develop and implement a focused line of research. While the program offers a full range of courses for the environmental health concentration of the Master of Public Health, the program is also developing a research base in chemical contaminants and human health, with special emphasis on the unique environment of the state of Florida. The University of Florida is a comprehensive Research I institution. UF has a remarkably wide range of academic departments and programs (www.ufl.edu) that enhance instructional and research programs on human health and the environment, such as the Center for Environmental and Human Toxicology, the Department of Environmental Engineering, and agricultural and nutritional sciences departments in the College of Agricultural and Life Sciences. UF encourages cross-college collaborations. The College of Public Health and Health Professions is part of the Universitys Health Science Center, which also includes the Colleges of Medicine, Pharmacy, Nursing, Dentistry, and Veterinary Medicine. For more information on the College of Public Health and Health Professions, please refer to www.phhp.ufl.edu. Application review begins April 2, 2007 and will continue until an applicant pool has been established. Applicants should submit a letter of interest referencing position 00023598, a CV, and three letters of recommendation to Dr. Natalie Freeman, Chair, Environmental Health Search Committee, College of Public Health and Health Professions, P.O.Box 100182, University of Florida, Gainesville, Florida 32610-0182. (Phone 352-392-4700x5545 , Fax 352-392-4707) The University of Florida is An Equal Opportunity Employer. Individuals with minority and/or disability status are encouraged to apply. If an accommodation due to a disability is needed to apply for this position please call 352-392-1251 or TDD 352-392-7056.