Toxicology Track

Weekly Newsletter of the MSU Center for Integrative Toxicology
Director: Norbert Kaminski/Editor: Lois Furry

August 27, 2007, Vol. 30, Number 30

Seminar/Grants/Workshop//Positions

Seminar

*The Department of Pharmacology and Toxicology presents Colin North, graduate student, to speak on "In Vivo and In Vitro Disruption of B Lymphocyte Differentiation by 2,2,7,8-Tetracholorodibenzo-Para-Dioxin (TCDD)" on Wednesday, August 29, 2007 at 12 noon in B448-9 Life Sciences. 

*Fulfills seminar requirements for the Environmental and Integrative Toxicological Sciences Graduate Programs.  Seminars that fulfill this requirement are archived at http://www.cit.msu.edu/Graduate%20Program/seminars.html.

Grants

Patricia Ganey and Timothy Zacharewski received $357,938 from the National Institutes of Health for "Gene Expression In Drug Inflammation Models as Predictive of Idiosyncratic ADRS."

John LaPres received $320,875 from the National Institutes of Health for "Hypoxia and an Epigenetic Mechanism for Toxicity."

Bruce Uhal received $212,629 from the U.S. Public Health Service for "Control of Type II Pheumocyte Proliferation."

Timothy Zacharewski and Jack Harkema received $543,226 from the National Institutes of Health for "Metabolic Assessment of Estrogenic Endocrine Disruptors."

Timothy Zacharewski, Chia-Cheng Chang, Christina Chan, and Jack Harkema received $357,938 from the National Institutes of Health for "Human Stem Cells for Toxicity Screening."

Workshop

The MSU CIT Superfund Program, Research Translation Core, is hosting a one-day workshop on September 19, 2007 at the MSU Kellogg Center to review and exchange ideas concerning the findings of the recently releases studies by the National Academy of Science and the World Health Organization on dioxin and dioxin-like compounds, and how these findings may be used in formulating national and international environmental policies and regulations. As part of the Superfund Basic Research Program grant to MSU from the National Institute of Environmental Health Science, this workshop is being provided free-of-charge to all participants, but seating capacity is limited.  Ensure your place by calling 517-353-6469 or e-mailing tox@msu.edu as soon as possible.  Overnight accommodations are available at area hotels. An informational flyer is available at superfund workshop.

PACS Testing, Consulting and Training will provide short courses at Chicago in September, Pittsburg in October, Atlanta in November; and Orlando in December. For a complete schedule and course offerings, check the PACS website at http://pacslabs.com or call 724. 457. 6756.

Positions

Syngenta Crop Protection, Inc., a worldwide leader in the area of plant protection seeks pesticide risk assessor for an open position in the Americas Human Safety Department in Greensboro, North Carolina. Experience in assessing chemical exposures from dietary, applicator or residential routes is preferred, but not required. Experience with advanced modelling techniques a plus. Candidates must possess at least a BS in chemistry, biology, industrial hygiene or a related field. Advanced degree and/or risk assessment experience is preferred. Good oral and written communication skills as well as interpersonal skills are a must. Email cover letter and resume to Dr. Nina E. Heard: nina.heard@syngenta.com.

The National Institute of Environmental Health Sciences and the National Toxicology Program seek applicants for a Chemist position located in the Laboratory of Pharmacology and Chemistry (LPC), Environmental Toxicology Program, Division of  Intramural Research, NIEHS.  The LPC uses the approaches and techniques of pharmacology, biochemistry, molecular biology, and chemistry to study the processes of exposure and effect of environmental chemicals.  Our group provides chemistry resources for the National Toxicology Program and the Division of Intramural Research, including the assessment of chemical distribution and biotransformation.   The successful candidate will serve as Discipline Leader for Absorption Distribution Metabolism, Excretion (ADME) studies for the Division of Intramural Research (DIR) and the National Toxicology Program (NTP). The NTP is an interagency program whose mission is to evaluate agents of public health concern by developing and applying tools of modern toxicology and molecular biology.  If selected, you will lead, plan, and design multiple concurrent studies of the fate of chemicals in vivo (chiefly in rodent models) as well as the mechanism of metabolism and mechanisms of toxicity. As a member of NTP Design Teams, you are responsible for evaluating ADME data from literature or other sources; designing and overseeing ADME studies conducted through contracted resources; writing the ADME section of NTP technical reports; and acting as the Program ADME technical expert and consultant. For more information, or to apply, go to http://jobsearch.usajobs.opm.gov/a9nih.asp.  Job Announcement Number: HHS/NIH-2007-0739.

Human Genome Sciences, Inc. located in the Washington, DC metro  has a Toxicolgist II position open.  The major responsibility of the successful candidate will be to design and implement the nonclinical safety assessment program for biotherapeutic compounds in development. Additional roles may include addressing mechanistic toxicology issues arising from nonclinical or clinical studies and providing toxicology expertise to other functional areas. To succeed in this challenging role, the ideal candidate will possess a PhD in toxicology, pharmacology or related discipline and 4-7 years of toxicology experience in a contract research organization or within the pharmaceutical or biopharmaceutical industry. Experince with large molecules and preferably on advanced stage programs preferred. Excellent written and verbal communication and presentation skills are required. Experience and knowledge of GLPs is ideal. Familiarity in the development of therapeutics used for biodefense and previous direct interaction with regulatory agencies are considered desirable. Please visit http://www.hgsi.com for further information on the company and to apply on-line for this position.

Kelly Scientific Resources located in Ontario, Canada has an opening for a Senior Toxicologist in Food and Nutrition. The ideal incumbent will have at least 10-15 years of relative job experience and a post graduate degree in toxicology from a recognized University. This is a full time, salaried position with an excellent package worth $120-$150K/annum.  For more information, go to http://ca.livejobs.recruitadvantage.com/job/apply_job_online.cfm?id=59499&from=ScienceCareers.

Two postdoctoral positions in NIH training grant are immediately available for highly motivated individuals with PhD in molecular biology/biochemistry/toxicology or related discipline and seeking to build a career in inflammatory lung diseases. The lab is interested in basic mechanistic and translational research focusing on bzip transcription factor, Nrf2. Previous work from the lab using mice models have demonstrated that this transcription factor determines the susceptibility and severity of emphysema, asthma and various pulmonary diseases by regulating environmental stress response- http://www.jhsph.edu/Dept/EHS/Faculty/biswal/index.html.  The project involves the molecular mechanism of Nrf2 dependent regulation of stress response and inflammation in emphysema, neonatal lung injury and asthma as well as translational aspect of targeting this transcription factor for intervening diseases in preclinical models and clinical trials. Individuals with a productive track record and experience in molecular biology/toxicology/ biochemistry or pathophysiology in mice models are encouraged to apply. These are NIH training grant positions so they are restricted to US citizens/permanent residents. Send CV with names of 3 references to Shyam Biswal, School of Public Health, Johns Hopkins University by email biswal2006@gmail.com. 

This newsletter is produced and distributed weekly by the Center for IntegrativeToxicology. We appreciate suggestions regarding information that might be included in this publication. To be added to the e-mail list, send your name and e-mail address to: Lois Furry, Editor, Center for Integrative Toxicology, Michigan State University, 165C Food Safety and Toxicology Building, East Lansing, MI 48824; furry@msu.edu; 517/353-6469(phone), 517/355-4603(fax).