Toxicology Track

Weekly Newsletter of the MSU Center for Integrative Toxicology
Director: Norbert Kaminski/Editor: Lois Furry

September 5, 2007, Vol. 30, Number 31

Seminars this week/Seminars upcoming/Publications/Workshops/Position/Fellowship

Seminars this week

The Department of Biochemistry and Molecular Biology present Ken Cadigan, University of Michigan, to speak on "Wnt Signaling: How Does the Signal Find the Right Targets and What Happens After it Does?" on Thursday, September 6, 2007 at 11:30 a.m. in 101 Biochemistry.

The Department of Geological Sciences and Shell Oil Company present James J. Butler, Darcy Lecturer, Kansis Geological Survey, University of Kansas, to speak on "Getting the Information Ground Water Modelers Need: A Report from the Field" on Thursday, September 6, 2007 at 12 noon in 204 Natural Science Building.

The Quantitative Biology and Modeling Institute present Jong-in Hahm, Department of Civil Engineering, Pennsylvania State University, to speak on "Engineering Novel Nanomaterials for Enhanced Biomedical Detection" on Friday, September 7, 2007 at 11:30 a.m. in 1400 Biomedical & Physical Sciences Building.

Seminars upcoming

The Department of Food Science and Human Nutrition presents Stephen D. Hursting, PH.D., MPH, University of Texas at Austin and UT_MD Anderson Cancer Center, to give the G. Malcolm Trout Visiting Scholar Lecture on "Diet, Obesity, and Cancer Prevention" on Monday, September 17, 2007 at 7 p.m. in the Lincoln Room at the MSU Kellogg Center. Reception at 6 p.m.

Publications

The Effects of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) on Mink (Mustela vison) Reproduction and Kit Survivability and Growth. Beckett KJ, Yamini B, Bursian SJ. Arch Environ Contam Toxicol. 2007 Aug 3; [Epub ahead of print]

Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. Shaw PJ, Hopfensperger MJ, Ganey PE, Roth RA. Toxicol Sci. 2007 Aug 19; [Epub ahead of print]

The Role of Tumor Necrosis Factor alpha in Lipopolysaccharide/Ranitidine-induced Inflammatory Liver Injury. Tukov FF, Luyendyk JP, Ganey PE, Roth RA. Toxicol Sci. 2007 Aug 13; [Epub ahead of print]

Modulation Of Airway Responses To Influenza A/PR/8/34 By Delta-9-Tetrahydrocannabinol In C57BL/6 Mice. Buchweitz JP, Karmaus PW, Harkema JR, Williams KJ, Kaminski NE. J Pharmacol Exp Ther. 2007 Aug 28; [Epub ahead of print]

High-Performance Gradient Elution: The Practical Application of the Linear-Solvent-Strength Model By Lloyd R. Snyder (LC Resources, Inc., Orinda, CA) and John W. Dolan (LC Resources, Inc., Amity, OR). J. Wiley & Sons, Inc.: Hoboken, NJ. 2007. xxviii + 462 pp. $115.00. ISBN 0-471-70646-9. McGuffin VL. J Am Chem Soc. 2007 Jul 11;129(27):8669-70. Epub 2007 Jun 19.

3,3'-Diindolylmethane stimulates murine immune function in vitro and in vivo. Xue L, Pestka JJ, Li M, Firestone GL, Bjeldanes LF. J Nutr Biochem. 2007 Aug 16; [Epub ahead of print]

Pulmonary response to airway instillation of autologous blood in horses. Derksen FJ, Williams KJ, Uhal BD, Slocombe RF, de Feijter-Rupp H, Eberhart S, Berney C, Robinson NE. Equine Vet J. 2007 Jul;39(4):334-9.

Differences in Sympathetic Neuroeffector Transmission to Rat Mesenteric Arteries and Veins as Probed by In Vitro Continuous Amperometry and Video Imaging. Park J, Galligan JJ, Fink GD, Swain GM. J Physiol. 2007 Aug 30; [Epub ahead of print]

A Large Gene Cluster in Burkholderia xenovorans Encoding Abietane Diterpenoid Catabolism. Smith DJ, Park J, Tiedje JM, Mohn WW. J Bacteriol. 2007 Sep;189(17):6195-204. Epub 2007 Jun 22.

Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy. Wang Q, Garrity GM, Tiedje JM, Cole JR. Appl Environ Microbiol. 2007 Aug;73(16):5261-7. Epub 2007 Jun 22.

Membrane Channel Connexin 32 Maintains Lin(-)/c-kit (+) Hematopoietic Progenitor Cell Compartment: Analysis of the Cell Cycle. Hirabayashi Y, Yoon BI, Tsuboi I, Huo Y, Kodama Y, Kanno J, Ott T, Trosko JE, Inoue T. J Membr Biol. 2007 Jul 15; [Epub ahead of print]

Workshops

The MSU CIT Superfund Program, Research Translation Core, is hosting a one-day workshop on September 19, 2007 at the MSU Kellogg Center to review and exchange ideas concerning the findings of the recently releases studies by the National Academy of Science and the World Health Organization on dioxin and dioxin-like compounds, and how these findings may be used in formulating national and international environmental policies and regulations. As part of the Superfund Basic Research Program grant to MSU from the National Institute of Environmental Health Science, this workshop is being provided free-of-charge to all participants, but seating capacity is limited. Ensure your place by calling 517-353-6469 or e-mailing tox@msu.eduassoon as possible. Overnight accommodations in the East Lansing area are available at area hotels. For more information on the workshop go to flyer.

PACS Testing, Consulting and Training will provide short courses at Chicago in September, Pittsburg in October, Atlanta in November; and Orlando in December. For a complete schedule and course offerings, check the PACS website at http://pacslabs.com or call 724. 457. 6756.

Position

A postdoctoral research position is available to study the molecular mechanisms underlying drug-induced liver injury (DILI) at the University of Connecticut School of Pharmacy. Research is focused on the elucidation of mechanisms of mitochondrial injury and the related signaling pathways in human hepatocytes and in animal models of human disease. Duration: 1 year (initial contract), extension for second year possible. Starting date: immediately, or by agreement.Applicants should possess a PhD degree and a strong background in molecular toxicology. Experience in mitochondrial biochemistry, human hepatocyte culture, and transgenic mouse models is an asset. Competitive salary based on experience and qualifications, ample lab space and modern equipment, and a stimulating interdisciplinary environment ideally suited for cross-faculty collaborations. Please send by e-mail a detailed CV and the names and contact information of two references to: Urs A. Boelsterli, PhD, Professor and Boehringer-Ingelheim Endowed Chair in Mechanistic Toxicology, University of Connecticut School of Pharmacy, Department of Pharmaceutical Sciences, 69 North Eagleville Road, Unit 3092, Storrs, CT 06269-3092; Email: urs.boelsterli@uconn.edu; Phone: +1-860-486-8087; Website: http://pharmacy.uconn.edu/index.php.

Fellowship

The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is offering Graduate Fellowships for masters and doctoral level students in environmental fields of study. The deadline for receipt of pre-applications is October 23, 2007 at 4:00 PM EST. Master’s level students may receive support for a maximum of two years. Doctoral students may be supported for a maximum of three years, usable over a period of four years. The fellowship program provides up to $37,000 per year of support per fellowship. The URL is: http://es.epa.gov/ncer/rfa/2008/2008_star_fellow.html. Individuals must be citizens of the United States or its territories or possessions, or be lawfully admitted to the United States for permanent residence. Applicants do not need to be enrolled in or formally accepted in a full-time graduate program at the time they apply for a fellowship, but proof of enrollment or acceptance must be produced prior to the award of the fellowship. Applicants must be pursuing a master’s or doctoral degree in an environmental field of specialization. Applicants who are in a graduate program at the time of application and meet either of the following two criteria as of October 23, 2007 ARE NOT eligible to receive a fellowship: 1) have completed more than one year in your current master’s program; or 2) have completed more than four years in your current doctoral program. However, applicants enrolled in a master’s program who intend to pursue a doctoral degree beginning in the fall of 2008 may apply for a doctoral fellowship. Eligible fields of study include: Environmental Engineering (limited to pollution prevention; includes sustainability); Environmental Engineering (limited to treatment and remediation; Environmental Chemistry and Environmental Materials Science; Microbiology; Molecular Biology (includes genomics, proteomics, toxicodynamics, toxicology, and bioinformatics); Public Health Sciences (includes environmental epidemiology, biostatistics, and health physics); Human Health Risk Assessment; Estuarine Processes (limited to pollution research such as harmful algal blooms);Terrestrial Systems Ecology (limited to soils and plants that can serve as a medium for contaminant transport);andTerrestrial Systems Ecology (work should relate to pollutant effects on animals and/or habitat).