Patricia E. Ganey

Professor of Pharmacology and Toxicology.

214 Food Safety Bldg. 
517-432-1761 
E-mail: Ganey@msu.edu

Research Interests:
Dr. Ganey's research interests lie in the interaction of inflammation and chemically induced liver injury. For many chemicals of diverse structure and mechanism of action, ongoing inflammation makes the liver more sensitive to toxic effects. Among the chemicals for which this is true are some drugs and environmental contaminants. Dr. Ganey’s research focus is on understanding the mechanisms by which inflammation causes this change in sensitivity. She studies inflammatory cells, including neutrophils and liver macrophages, as well as soluble mediators, like cytokines. Of particular interest are the changes in gene expression and signal transduction pathways that lead to toxicity. One current project is aimed at examining the interaction of aryl hydrocarbon receptor ligands, like dioxin and polychlorinated biphenyls, with the inflammatory response and developing computational models for these responses. Another project involves inflammation/drug interaction that mimics idiosyncratic drug responses in people.

Educational Background:
University of Maryland, B.S., 1979, Biological Sciences 
Michigan State University, Ph.D., 1986, Pharmacology/Toxicology 

Selected Professional Activities:
Dr. Ganey has received the following honors: Hazelton Laboratories Corporation Predoctoral Fellowship, 1984; National Research Service Award, 1987-89; American Liver Foundation Postdoctoral Fellowship, 1987; Past President of the Michigan Regional Chapter of the Society for Toxicology, 2000-2001; the Pfizer Excellence in Research Award, 2002; Society of Toxicology Awards Committee, 2006; Chair of the Society of Toxicology, Member SErvices Strategy Committee, 2006. She completed postdoctoral training at the University of North Carolina, Chapel Hill. Dr. Ganey belongs to the American Society for Pharmacology and Experimental Therapeutics, the International Endotoxin Society, the Society of Leukocyte Biology, and the Society of Toxicology. Dr. Ganey is a faculty trainer for the NIEHS training grant.

Publications:

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