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Jack R. Harkema

Jack R. HarkemaUniversity Distinguished Professor, Pathobiology and Diagnostic Investigations

1129 FARM LN ROOM 212

Research Interests:
Dr. Harkema is widely recognized for his work in inhalation toxicology, nasal toxicology, and the toxicologic pathology of the respiratory tract in laboratory animals. His work is designed to understand the cellular and molecular mechanisms involved in the pathogenesis of airway injury caused by the inhalation of airborne pollutants. More specifically, his laboratory is investigating the roles of inflammatory cells and their mediators in the pathogenesis of airway epithelial alterations (e.g., apoptosis, necrosis, hyperplasia, metaplasia) in both the upper and lower respiratory tract after exposure (and co-exposure) to various inhaled xenobiotic agents (e.g., particulate matter, ozone, endotoxin, mycotoxins). His research also focuses on identifying biological factors (e.g., genetics, age, pre-existing disease) responsible for increasing airway susceptibility to toxicant-induced injury. The long-range goal of these studies are to understand the basic mechanisms of airway cell injury and repair in order to better prevent or treat the adverse effects of airborne pollutants.

Educational Background:
Calvin College, B.S., Biology/Chemistry, 1975
Michigan State University, M.S., Physiology, 1977
Michigan State University, D.V.M., cum laude, 1980
University of California-Davis, Ph.D., 1985, Comparative Pathology

Selected Professional Activities:
Dr. Harkema's honors and awards include the New Investigator Award, Inhalation Toxicology Specialty Session, Society of Toxicology, 1987; the Pfizer Award for Research Excellence, College of Veterinary Medicine, MSU, 2001; the University Distinguished Professor Award, MSU, 2003; and the Distinguished Faculty Award College of Veterinary Medicine, MSU, 2006. Dr. Harkema belongs to the following societies: American Association for the Advancement of Science; American College of Veterinary Pathologists; American Thoracic Society; American Veterinary Medical Association; Phi Zeta; Sigma Xi, Society of Toxicologic Pathologists; and the Society of Toxicology. Dr. Harkema is a faculty trainer for the NIEHS training grant.


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Laboratory Trainees:

  • Katryn Allen, Postdoctoral, Veterinary Medicine
  • Christina Brandenberger, Postdoctoral, Pathobiology and Diagnostic Investigation